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Cancer immunotherapy

Polypeptide agonists of innate immune sensors

Nature Biomedical Engineering volume 8, pages 495–496 (2024)Cite this article

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The physicochemical properties of cationic helical polypeptides can be optimized to induce endoplasmic reticulum stress in antigen-presenting cells so as to elicit antitumour innate immune responses.

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Fig. 1: The degree of helicity and serum stability of a polypeptide agonist affects its antitumour activity.

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Authors and Affiliations

  1. Harvard-MIT Division of Health Sciences & Technology, Massachusetts Institute of Technology, Cambridge, MA, USA

    Michelle Z. Dion

  2. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA

    Michelle Z. Dion & Natalie Artzi

  3. Department of Medicine, Division of Engineering in Medicine, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Michelle Z. Dion & Natalie Artzi

  4. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA

    Michelle Z. Dion & Natalie Artzi

Authors
  1. Michelle Z. Dion
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  2. Natalie Artzi
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Correspondence to Natalie Artzi.

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The authors declare no competing interests.

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Dion, M.Z., Artzi, N. Polypeptide agonists of innate immune sensors. Nat. Biomed. Eng 8, 495–496 (2024). https://doi.org/10.1038/s41551-024-01212-8

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