Extended Data Fig. 4: Tracking the response of HL60 cells under apoptotic stress. | Nature Biomedical Engineering

Extended Data Fig. 4: Tracking the response of HL60 cells under apoptotic stress.

From: Profiling protein–protein interactions to predict the efficacy of B-cell-lymphoma-2-homology-3 mimetics for acute myeloid leukaemia

Extended Data Fig. 4

a, Schematics for the intracellular PPI profile changes (left), and the result of flow cytometry analysis after Annexin V/Propidium iodide staining through the progression of apoptosis pathway (right). Viability represents the double negative populations after Annexin V/Propidium iodide staining and analyzed with flow cytometry. b,c, Population changes of HL60 cells at different time points through the treatment of drug with Annexin V/Propidium iodide staining. (b) 2 μM of staurosporine, (c) 300 nM of ABT-199.

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