Extended Data Fig. 4: Treatment with editor-containing nanoparticles restores visual responses in rd12 mice. | Nature Biomedical Engineering

Extended Data Fig. 4: Treatment with editor-containing nanoparticles restores visual responses in rd12 mice.

From: Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations

Extended Data Fig. 4

(a) Visually evoked potentials (VEPs) in the superior colliculus (SC) for untreated WT mice (black); rd12 mice treated with free RNP (green); rd12 mice treated with ABE RNP LNP (purple); rd12 mice treated with PE RNP LNP (red); and untreated rd12 mice (orange). Bar plots represent the summary of the VEPs from all tested animals. (b) Same analysis as in (A) performed for the primary visual cortex (V1). (c) Overlapped examples of histograms for single-neuron flash responses. (d) Single-cell examples of selective neurons recorded in the SC. The tuning curves present orientation-selective cells, spatial frequency, and temporal frequency tuning curves for the tested mice. Numbers on the graphs indicate HWHH, optimal spatial frequency, and optimal temporal frequency.

Source data

Back to article page