Extended Data Fig. 1: Validation of the monocytic signature. | Nature Biomedical Engineering

Extended Data Fig. 1: Validation of the monocytic signature.

From: Characterization of tumour heterogeneity through segmentation-free representation learning on multiplexed imaging data

Extended Data Fig. 1

a, Schematic of WTA data processing pipeline. b, Cell type composition across biopsies. c, Elbow plot of biopsies ranked by cosine similarity to signature C10, colored by survival. d, Survival analysis of C10-similar patients vs other patients. e, Cell level enrichment score comparison between naïve lung and tumors. Error bars in violin plots indicate minimum, mean, and maximum values within each group. P-value is calculated by Independent Samples T-test. f, Single cell analysis on tumor and normal monocytes. Distribution of monocytes in tumor and naive mouse lung (left). Extracellular Matrix (ECM) pathway gene expression in naive (middle) and tumor (right) lung, colored by enrichment score. g, Schematic of in vitro monocyte co-culture experiments. h, Log2 fold-change of ECM-related gene expression of the treatment group (24 and 48 hours) compared with the control group.

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