Extended Data Fig. 5: [18F]FDG-PET/CT imaging is unable to differentiate significant differences in the P301S (PS19) mouse brain.

a, Summed [18F]FEDV–PET/MRIs (45–60 min) SUVAVG analysis shows slightly increased [18F]FDG–PET signal in all regions of interest (ROIs) in PS19 mice (red) than in age-matched WT mice (gray). ROIs were generated using the Ma-Benveniste-Mirrione atlas on MRI, and PET signal in ROIs was quantified (n = 4 for each group; ns, two-way ANOVA with Šídák’s multiple comparison). b, Summary of all p values calculated for [18F]FDG-PET comparison in PS19 vs WT mice.