Extended Data Fig. 1: In vivo two-photon fluorescence images. | Nature Biomedical Engineering

Extended Data Fig. 1: In vivo two-photon fluorescence images.

From: Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes

Extended Data Fig. 1

In vivo two-photon fluorescence images of 12-month-old and 6-month-old APP/PS1 mice after being administered with Gd-QM-FN (2.35 mg kg−1) & FITC (50 mg kg−1) via tail vein at 2 min (a) and 10 min (b) post-injection. Channel 1: λex = 900 nm, λem = 660–750 nm. Channel 2: λex = 900 nm, λem = 575–645 nm. Note: white single-arrows refer to Aβ plaques, white double-arrows refer to cerebral amyloid angiopathy. The experiments in panels a and b were performed with 3 biological replicates and single measurement per mouse.

Back to article page