Extended Data Fig. 7: On-chip response curves under treatment of 2nd-and 4th-gen CAR T cells of two leukaemia patients. | Nature Biomedical Engineering

Extended Data Fig. 7: On-chip response curves under treatment of 2nd-and 4th-gen CAR T cells of two leukaemia patients.

From: Bioengineered immunocompetent preclinical trial-on-chip tool enables screening of CAR T cell therapy for leukaemia

Extended Data Fig. 7

(a,b) Comparative analysis of 2nd-gen 4-1BBζ-CAR T cells (CAR19) and 4th-gen 4-1BBζ-CAR-IL18 T cells (CAR19-IL18) at doses of 10,000, 1,250 and 625 CAR T cells for patient donor 1 (PD1) and patient donor 2 (PD2). Data was collected from three technical replicates (n = 3). (c) Summary of comparative analysis of CAR19 and CAR19-IL18 T cells at 10,000 and 1,250 CAR T cells. Data was collected from six technical replicates (n = 6), mean and s.e.m.

Source data

Back to article page