Fig. 7: In vivo human brain tissue microstructure results.

White and grey matter microstructural estimates obtained from biophysical modelling of diffusion MRI data acquired in 10 age- and sex-matched healthy adults scanned on Connectome 2.0 and Connectome 1.0 scanners. a, Axon diameter index maps estimated from the AxCaliber-SMT model averaged across individuals. b, Histogram of axon diameter indices from Connectome 2.0 and Connectome 1.0 extracted from a representative region of interest in the posterior corona radiata. c, Estimates of intrasoma signal fraction (left), intraneurite signal fraction (centre) and soma radius (right) from fitting of the SANDI model. SANDI estimates were averaged across individuals and projected onto the cortical surface. Inset: intrasoma signal fraction demonstrates estimates within sensorimotor cortex, delineated as Brodmann areas 4, 3a, 3b and 1.