Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Image processing

Artificial intelligence advances skull stripping across lifespan

A skull-stripping artificial intelligence model leveraging personalized prior knowledge from brain atlases generates consistent brain extraction across diverse age groups, scanners and protocols.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Brain charts on total volumes from LifespanStrip and Bethlehem et al.

References

  1. Rehman, H. Z. U., Hwang, H. & Lee, S. Appl. Sci. 10, 1773 (2020).

    Article  Google Scholar 

  2. Wang, L. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-024-01337-w (2025).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Sun, Y. et al. IEEE Trans. Med. Imaging. 40, 1363–1376 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Bethlehem, R. A. I. et al. Nature 604, 525–533 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Paus, T., Brook, J. R., Keyes, K. & Pausova, Z. (eds) Principles and Advances in Population Neuroscience (Springer, 2024).

  6. Schwartz, E. et al. Nat. Commun. 14, 2252 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Zhou, Q. et al. Dev. Cogn. Neurosci. 52, 101028 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Zhou, Z.-X. et al. Sci. Bull. 68, 795–799 (2023).

    Article  Google Scholar 

  9. Zhang, L. & Xue, G. Nat. Hum. Behav. 9, 1070–1072 (2025).

    Article  PubMed  Google Scholar 

  10. Lu, B. et al. Sci. Bull. 69, 1536–1555 (2024).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Xi-Nian Zuo.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, P., Wang, YS. & Zuo, XN. Artificial intelligence advances skull stripping across lifespan. Nat. Biomed. Eng 9, 1180–1181 (2025). https://doi.org/10.1038/s41551-025-01458-w

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41551-025-01458-w

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing