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Nanomedicine

Metabolic reprogramming with ultrasound-responsive nanovesicles

Nature Biomedical Engineering (2025)Cite this article

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Ultrasound-responsive lipid nanoparticles encapsulating thylakoid fragments sourced from plants and ascorbic acid restore mitochondrial function, treating acute kidney injury in mice and pigs.

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Fig. 1: Schematic illustration of acute kidney injury treatment using ultrasound-responsive nanovesicles.

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Authors and Affiliations

  1. Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA

    Jessica C. Hsu & Weibo Cai

  2. Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA

    Jessica C. Hsu & Weibo Cai

  3. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Jingwei Zhou

Authors
  1. Jessica C. Hsu
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  2. Jingwei Zhou
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  3. Weibo Cai
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Corresponding author

Correspondence to Weibo Cai.

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Competing interests

W.C. declares competing interests with the following corporations: Portrai, Inc., rTR Technovaation Corporation and Four Health Global Pharmaceuticals, Inc. The other authors declare no competing interests.

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Hsu, J.C., Zhou, J. & Cai, W. Metabolic reprogramming with ultrasound-responsive nanovesicles. Nat. Biomed. Eng (2025). https://doi.org/10.1038/s41551-025-01460-2

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