Extended Data Fig. 5: Converting the disulfide bond to a thioacetal bond prevents mimotope binding to FMC63IgG. | Nature Biomedical Engineering

Extended Data Fig. 5: Converting the disulfide bond to a thioacetal bond prevents mimotope binding to FMC63IgG.

From: Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells

Extended Data Fig. 5

a) schematics showing the chemical structure and conversion of the disulfide bond to a thioacetal bond. Created in BioRender. Ma, L. (2025) https://BioRender.com/xd8q66t (b) MALDI spectrum showing the purification of expected mimotope with a thioacetal bond. (c) Representative histogram showing FMC63IgG binding to target cells labeled with amph-mimotopeF12 variants.

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