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RNA MODIFICATION

An additional class of m6A readers

Nature Cell Biology volume 20, pages 230–232 (2018)Cite this article

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N6-methyladenosine (m6A) mRNA modification influences mRNA fate by stimulating recruitment of m6A reader proteins. A previously unappreciated class of m6A reader proteins is now shown to use a common RNA-binding domain and flanking regions to selectively bind m6A-containing mRNAs, increasing their translation and stability.

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Fig. 1: Three classes of m6A reader proteins.

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Authors and Affiliations

  1. Medical Scientist Training Program, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA

    Katherine I. Zhou

  2. Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA

    Tao Pan

  3. Institute of Biophysical Dynamics, University of Chicago, Chicago, IL, USA

    Tao Pan

Authors
  1. Katherine I. Zhou
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  2. Tao Pan
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Correspondence to Tao Pan.

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The authors declare no competing interests.

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Zhou, K.I., Pan, T. An additional class of m6A readers. Nat Cell Biol 20, 230–232 (2018). https://doi.org/10.1038/s41556-018-0046-y

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