Exosomes are heterogeneous, nanoscale vesicles that mediate cellular communication. A study now leverages a size separation strategy to identify sub-classes of nanoparticles, revealing a subtype without an encapsulating membrane and variation in vesicle cargo, suggesting that size is not the only driver of heterogeneity.
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References
Lötvall, J. et al. J. Extracell. Vesicles 3, 26913 (2014).
Peinado, H. et al. Nat. Med. 18, 883–891 (2012).
van der Vos, K. E. et al. Neuro. Oncol. 18, 58–69 (2016).
Clancy, J. W. et al. Nat. Commun. 6, 6919 (2015).
Sung, B. H., Ketova, T., Hoshino, D., Zijlstra, A. & Weaver, A. M. Nat. Commun. 6, 7164 (2015).
Kamerkar, S. et al. Nature 546, 498–503 (2017).
Zhang, H. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0040-4 (2018).
Kowal, J. et al. Proc. Natl Acad. Sci. USA 113, 968–77 (2016).
Xu, R., Greening, D. W., Rai, A., Ji, H. & Simpson, R. J. Methods 87, 11–25 (2015).
Crescitelli, R. et al. J. Extracell. Vesicles 2, 20677 (2013).
Melentijevic, I. et al. Nature 542, 367–371 (2017).
Ma, L. et al. Cell Res. 25, 24–38 (2015).
Minciacchi, V. R. et al. Cancer Res. 77, 2306–2317 (2017).
Minciacchi, V. R., Freeman, M. R. & Di Vizio, D. Semin. Cell Dev. Biol. 40, 41–51 (2015).
Ostrowski, M. et al. Nat. Cell Biol. 12, 19–30 (2010).
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Zijlstra, A., Di Vizio, D. Size matters in nanoscale communication. Nat Cell Biol 20, 228–230 (2018). https://doi.org/10.1038/s41556-018-0049-8
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DOI: https://doi.org/10.1038/s41556-018-0049-8
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