Supplementary Figure 8: Adult mice with global AMPK deletion has normal lifespan.
From: AMP kinase promotes glioblastoma bioenergetics and tumour growth
a, WB showing efficiency of Cre-recombination in the indicated tissues. Expression of total and active AMPK in control and AMPK-deleted tissues in mice are shown. β actin was used as loading control. Note that AMPK α subunits are unstable in the absence of β subunits. b, Kaplan-Meier survival curve of control and AMPK β subunit-deleted mice. (n = 12 mice/genotype). c, Body weight of control and AMPK β subunit-deleted mice are shown. Note: AMPK α subunit deleted mice (genotype #2) also had normal lifespan and bodyweight. (n = 12 mice/genotype). Error bars; mean +/- S.D. Statistical significance in above experiments was assessed using two-tailed t-test.
