Supplementary Figure 7: Durable response to RMC-4550 in NF1LOF model. | Nature Cell Biology

Supplementary Figure 7: Durable response to RMC-4550 in NF1LOF model.

From: RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers

Supplementary Figure 7

(a) Western blot demonstrates loss of NF1 protein in TH77 PDX model. A previously published EGFRL858R, NF1wt PDX model is shown as comparator1. (b) Tumor specimen of vehicle and RMC-4550 treated groups were analyzed regarding their general tissue morphology by H&E stain (representative of n = 3 independent samples per treatment arm, 10X magnification, size bar: 100 nm). Significant areas of necrosis (arrows) were present in tumors of RMC-4550 treated animals.

Back to article page