Supplementary Figure 6: Genes enriched in m6As have CpG-rich promoters.
From: The RNA N6-methyladenosine modification landscape of human fetal tissues
a. Western blots of FLAG or ß-ACTIN from SFB-METTL3 Hela cells before and after doxycycline induced expression. Unprocessed data is shown in Supplementary Figure 8. The western blot was performed twice with similar results, and a representative figure was shown. b. Enrichment of METTL3 occupancy in the promoters of m(6)A modified genes over unmodified genes. N = 19801, 18676, 18439, 18030, 17567, 17374, 17778 and 17303 genes in brain, heart, kidney, liver, lung, muscle, placenta and stomach, respectively. One-sided fisher’s exact test, P <2.2E-16 (see source data in Supplementary Table 5). c. Guitar plot of m(6)As distribution on genes with CpG-rich or poor promoters.
