Supplementary Figure 8: The expression and methylation levels of IFFO1 and LMNA in multiple cancer cell lines from The Cancer Cell Line Encyclopedia (CCLE).
a-c, The expression (a) and methylation (b) levels of IFFO1 gene and their correlation (c) in CCLE. Correlation Coefficient (R) and P Value (PR) were calculated using Pearson Correlation; n = 834 cell lines (c). Sample sizes in (a, b) were indicated in the brackets. d-f, The expression (d) and methylation (e) levels of LMNA gene and their correlation (f) in CCLE. Correlation Coefficient (R) and P Value (PR) were calculated using Pearson Correlation; n = 234 cell lines (f). Sample sizes in (d, e) were indicated in the brackets. g, Plot of expressions of IFFO1 and LMNA in cancer cell lines of CCLE. Red and blue boxes indicate IFFO1-positive LMNA-negative and IFFO1-negative LMNA-positive cell lines, respectively. Most IFFO1-positive LMNA-negative cells belong hematological malignancies. All the CCLE data and analysis were accessed through the website (https://portals.broadinstitute.org/ccle). Statistical source data including precise P values are shown in Supplementary Table 5.
