Extended Data Fig. 3: TAD and compartment domain boundaries form with similar kinetics.
From: A chromosome folding intermediate at the condensin-to-cohesin transition during telophase
a, Aggregate Hi-C data binned at 40 kb resolution at domain boundaries (top = all 724 boundaries, middle = 657 TAD boundaries, bottom = 67 compartment boundaries) at different time points after release from prometaphase. b, Average insulation profile across averaged domain boundaries shown in panel a (left = TAD boundaries, right = compartment boundaries) for different time points. c, Normalized strength for domain boundaries as a function of time after release from prometaphase. The strength for each of these features was set at 1 for the 8 hour time point. TAD boundaries and compartment boundaries form with similar kinetics. Three independent replicate experiments yielded similar results. Source Data are provided in Source Data Extended Data Fig. 3.
