Extended Data Fig. 2: Compartment analysis for time course replicate 1.
From: A chromosome folding intermediate at the condensin-to-cohesin transition during telophase
a, Principal component 1 (PC1) along Chromosome 14 for Hi-C data obtained from cells at different time points after release from prometaphase. Principal component analysis was performed on Hi-C data binned at 200 kb resolution. PC1 detects A and B compartments starting at t = 3 hours. Lower left corner represents Pearson correlation value of each track compared to non-synchronous PC1. b, Principal component 3 (PC3) along Chromosome 14 for Hi-C data obtained from cells at different time points after release from prometaphase. Principal component analysis was performed on Hi-C data binned at 200 kb resolution. PC3 detects some A and B compartments starting at t = 2.75 hours, but at later time points, PC1 captures compartments. Lower left corner represents Pearson correlation value of each track compared to non-synchronous PC1. Three independent experiments were performed with similar results.
