Extended Data Fig. 7: Expression of Eomes or Brachyury downstream targets Mesp1, Msgn1, Mixl1, Foxa2 and Six2 in dKO cells activates specific ME gene programs. | Nature Cell Biology

Extended Data Fig. 7: Expression of Eomes or Brachyury downstream targets Mesp1, Msgn1, Mixl1, Foxa2 and Six2 in dKO cells activates specific ME gene programs.

From: Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state

Extended Data Fig. 7

a, Expression levels of Mesp1, Msgn1, Mixl1 and Foxa2 in WT, dKO and dKO cells induced with Eomes- or Brachyury- FL, VP16 and EnR rescue constructs. Expression levels are shown as log10 RPKM from n=3 biologically independent RNA-seq experiments. b-f, Expression levels of ME genes after induced expression of Mesp1 (b), Msgn1 (c), Mixl1 (d), Foxa2 (e) or Six2 (f) in dKO cells. Bars represent centred scaled counts from n=3 biologically independent RNA-seq experiments. Error bars indicate s.e.m.

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