Extended Data Fig. 6: Communities of mRNAs bound by SMN-primed ribosomes show reduced ribosome occupancy.
From: SMN-primed ribosomes modulate the translation of transcripts related to spinal muscular atrophy
a, Comparison between total RNA fold changes (SMA vs CTRL) in SMN-specific genes, binned in the 7 SMN-communities. Data were retrieved from Bernabò et al., 201711. Significant shifts in each community were identified with the two-sided one-sample Wilcoxon rank-sum test. The number of genes for each community is reported in Fig. 3f. b, Representative polysomal profiles obtained from CTRL and SMA mouse brains (early-symptomatic). c, Representative active RiboSeq coverage tracks for SMN-specific transcripts selected for validation by polysomal profiling. The average normalized coverage and the standard error among replicates are represented in each profile. The structure of the transcript, showing the boundaries of CDS and UTR regions, is outlined below each profile. Statistical source data are provided in Source data Extended data Fig. 6.
