Extended Data Fig. 6: Characterizing the effect of p53 on Notch gene expression and HSPC formation. | Nature Cell Biology

Extended Data Fig. 6: Characterizing the effect of p53 on Notch gene expression and HSPC formation.

From: Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h

Extended Data Fig. 6

a–h, WISH of WT sibling (a,e) and supt16h-/- embryos that are p53+/+ (b,f), p53+/- (c,g), or p53-/- (d,h) for notch1b (a-d) and runx1 (e-h) at 28 hpf. i-l, WISH for runx1 of embryos injected with p53-MO, notch1b-MO, or both MOs at 28 hpf. m-t, WISH of runx1 (m-p) and cmyb (q-t) for WT sibling or mib-/- embryos injected with p53-MO. Blue arrowheads indicate HSPCs. Bar, 100 μm.

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