Extended Data Fig. 10: Model of how Supt16h and P53 regulate HSPC specification through notch transcription. | Nature Cell Biology

Extended Data Fig. 10: Model of how Supt16h and P53 regulate HSPC specification through notch transcription.

From: Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h

Extended Data Fig. 10

a,b, In a wild-type settng, p53 (a) and phc1 (b) maintain baseline levels of accessibility and transcriptional expression. c,d, This results in normal transcription of Notch genes (c) and allows for proper specification of HSPCs (d). e, In supt16h mutants, the p53 gene locus is highly accessible, resulting in increased p53 mRNA and protein levels. f, p53 then binds to phc1, a repressor of Notch gene expression, to allow for its enhanced expression. g, PHC1, as part of PRC1, inhibits Notch signalling by acting as direct or indirect a transcriptional repressor of Notch genes. h, In the absence of Notch expression, HSPCs fail to specify.

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