Extended Data Fig. 5: A toxic form of Huntingtin (HTT96Q) triggers apoptosis.
From: Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition
(a,b) Expression of HTT96Q throughout the pouch (with rotund-gal4) triggers an increased rate of apoptosis relative to that seen with GFP expression, which is expected to be innocuous. c, Quantification of Dcp1 coverage in the two genotypes shown in panels a and b (n = 5 discs per genotype). Error bars denote standard deviation. For statistical analysis, a two-tailed unpaired t-test was carried out. **P = 4.11E-03. Scale bars represent 50 µm. Genotypes for each figure panel are available in Supplementary Table 1. Source data is available for this figure.
