Extended Data Fig. 2: Differential binding affinities of Ascl1 and Myod1 meditate distinct transcription factor actions.
From: Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes
a,b, Average normalized read counts of all peaks for (a) H3K27ac ChIP and (b) ATAC-seq in no-virus control (novir), Ascl1 (A1) and Myod1 (MD) samples 48 hr post-TF-induction, separated into Ascl1-enriched, Myod1-enriched and common peaks (from Fig. 2a). c, Gene ontology of nearest genes associated with a FLAG ChIP-seq peak that fall within the gene promoter or enhancer at Ascl1-enriched, Myod1-enriched and common peaks (from Fig. 2a) using DAVID v6.852. (d–g) Genome browser tracks showing FLAG ChIP signals and corresponding H3K27ac, ATAC-seq and RNA-seq signals for neurogenic genes, (d) Sox11 and (f) Syn2, and myogenic genes (e) Klhl41 and (g) Myog.
