Extended Data Fig. 9: Model of NFIB and NFIX Function in the HF SC Niche. | Nature Cell Biology

Extended Data Fig. 9: Model of NFIB and NFIX Function in the HF SC Niche.

From: NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices

Extended Data Fig. 9

Although our studies focused on using Sox9-CreER mice to ablate NFI proteins in the HF, we also show that LV-CreER ablation of NFI proteins in the epidermis does not affect its SCs or its differentiation program. Rather, NFIB and NFIX act on the bulge-SCs and without them, a primary scarring alopecia phenotype is generated. At the chromatin level, NFI proteins act in the bulge-SC niche to maintain chromatin accessibility of bulge-SC super-enhancers while repressing epidermal enhancers. When NFI proteins are absent, many bulge-SC super-enhancers are silenced while some epidermal enhancers become ectopically activated, leading to a lineage infidelity state.

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