Extended Data Fig. 5: Chronic viral infection reduces stem-cell function in ISCs.
a,b Ifit1 mRNA expression (a) and organoid-forming ability of FCM-sorted crypt epithelial cells (b) from uninfected and from 7 d post-infection of LCMV C13-infected WT mice. Data represent means ± s.d. of n=4 mice in (a), and n=6 mice in (b). Statistics were determined by two-tailed Mann-Whitney test. (c) Ileal sections from uninfected (5 mice, upper) and from LCMV C13 infected (7 mice, lower) WT mice stained with Alcian Blue. Right panel shows higher magnification of the indicated region. Scale bars: 200 μm (lower magnification images in c) and 20 μm (higher magnification images in c).
