Extended Data Fig. 4: Chromatin landscape of melanoma cultures.
From: Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma
a, Normalized ATAC-seq signal in melanocytic regions (n=6,669) and mesenchymal-like regions (n=13,453) as previously identified4 shows higher chromatin accessibility in melanocytic regions in melanocytic and intermediate cultures and lower chromatin accessibility in mesenchymal-like regions, and vice versa. b, Normalized ATAC-seq signal in SOX10-, FOS- and JUND-bound regions, as previously identified by ChIP-seq, shows contrasting chromatin accessibility of SOX10-bound regions between mesenchymal-like and melanocytic cultures, and a gradual decreased accessibility in AP-1-associated regions (FOS and JUND) going from mesenchymal-like, over intermediate to melanocytic cultures. c, Normalized ATAC-seq signal at IRF2 (top left), FN1 (top right), SOX9 (bottom left) and NFATC2 (bottom right) gene loci shows higher accessibility in intermediate and mesenchymal-like cultures compared to the extreme melanocytic cultures.
