Cellular plasticity allows tumours to adapt to and overcome therapeutic challenges. A recent study uncovered the gene regulatory networks that govern cell states and phenotype switching in melanoma, opening up possibilities to therapeutically target cell states or phenotypic plasticity to render melanoma cells more vulnerable to treatment.
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Aiello-Couzo, N.M., Kang, Y. A bridge between melanoma cell states. Nat Cell Biol 22, 913–914 (2020). https://doi.org/10.1038/s41556-020-0556-2
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DOI: https://doi.org/10.1038/s41556-020-0556-2
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Biopsy RNA-seq captures TROP-2–linked migration and clonal resistance to forecast aggressiveness in metastatic melanoma
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