Extended Data Fig. 6: The assembly state of initiator proteins impacts CME dynamics.
From: Liquid-like protein interactions catalyse assembly of endocytic vesicles
When Eps15 (green) and Fcho1 (magenta) exist in an unassembled, or dilute phase on the membrane surface, abortive structures are favored. In productive structures, Eps15 and Fcho1 assemble into a liquid protein phase capable of exchange with molecules in solution. Further assembly of Eps15 and Fcho1 into a gel or solid phase limits molecular exchange and promotes stalled endocytic structures.
