Fig. 1: Circulating APC subset diversity in COVID-19 from the discovery set. | Nature Cell Biology

Fig. 1: Circulating APC subset diversity in COVID-19 from the discovery set.

From: Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity

Fig. 1

a, Schematic of the experimental workflow. APCs were enriched from fresh PBMCs of healthy donors and patients with COVID-19 with either moderate or severe clinical symptoms at both day 1 and day 4 post hospital admission. The total APCs were sequenced using the 10X Genomics facility. b,c, Cellular maps of APC subsets (n = 42,784 cells) from the discovery set at single-cell resolution level displayed on UMAP dimension reduction based either on identified cell types (b) and severity (c). Proportions of the APC subtypes are displayed on the doughnut plot. d, UMAP plot of detected APC populations split by severity group (healthy controls and patients with moderate and severe COVID-19). The discovery set comprises a total of 12 samples (n = 2 controls, n = 4 moderate and n = 6 severe samples) collected from a total of seven patients and two healthy donors.

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