Extended Data Fig. 2: Maintenance of dysregulated patterns at time and patient levels.

Violin plot representation of a. HLA-II Module Score in CD1c+DC, and b. P53 pathway Module Score in pDC, both from the discovery set (composed of: n=2 HC, n=4 moderate and n=6 severe samples); asterisks above moderate indicate significance of moderate versus control and asterisks above severe indicate significance of severe versus control. Comparative analysis was performed using the two-sided Wilcoxon Rank-Sum test, P-values were adjusted to multiple testings using ‘Bonferroni’ correction. *P < 0.05, **P < 0.01, ***P < 0.001. c, Dot Plot representation of antiviral effector molecules in CD14+ Monocytes across patients, Percentage of cells expressing the respective gene is size-coded.