Extended Data Fig. 10: CTR1 sulfenylation in tissue resident cells is required for ischemia-induced angiogenesis in vivo.
From: Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis
A and B. Irradiated WT or mCTR1KI/KI mice were transplanted with BM from WT mice. After 6 weeks of BMT, mice were subjected to hindlimb ischemia and limb blood flow using a laser Doppler flow analyzer (A). CD31+ capillary density in ischemic gastrocnemius muscle at day 14 after ischemic injury were measured (B). (n = 6 mice per group, representative of two independent experiments, compared with two-way ANOVA followed by Bonferroni’s multiple comparison analysis (A) or two-tailed unpaired t-test (B), ***p < 0.001. Data are mean ± SEM). Source numerical data are available in source data.
