Extended Data Fig. 4: Compared to C24 or MS177N1, MS177 is much more potent in inhibiting tumor cell growth. | Nature Cell Biology

Extended Data Fig. 4: Compared to C24 or MS177N1, MS177 is much more potent in inhibiting tumor cell growth.

From: EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis

Extended Data Fig. 4

(a-c) Plots showing the growth inhibitory effect of various used concentrations (x-axis; in the log10 converted values) of either C24 (a), MS177 (b) or MS177N1 (c) using a panel of six MLL-r acute leukaemia cell lines (that is, MV4;11, RS4;11, MOLM-13, KOPN-8, THP-1 and EOL-1 cells), treated for 2, 4 or 6 days. Y-axis shows relative cell growth after normalization to DMSO-treated controls (n = 3; mean ± SD).

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