Extended Data Fig. 7: Epigenetic features of CEN and its sequence conservation across species.
From: Enhancer selection dictates gene expression responses in remote organs during tissue regeneration
a, A/B compartment analysis indicates a chromatin B to A compartment switch at cebpd and CEN loci. Dashed lines indicate cebpd and CEN region. b, Browser tracks indicating assays from this study and others. Brain ATAC-seq and Brain RNA-seq, uninjured and 7 days after CM ablation (7 dpi; this study); CM H3.3 occupancy, uninjured and 7 dpi (GSE81862); H3K27Ac occupancy, uninjured and 7 dpi (GSE75894); H3K27me3 and H3K4me3 occupancy in ventricular Gata4+ CMs, uninjured and 5 days post resection (GSE96928). Dashed lines indicate CEN. c, mVista plot of genomic regions around cebpd indicating high conservation of zebrafish CEN with cyprinid fish and low conservation with amphibians and mammals. Calculation window = 100 bp, conservation identity = 70%.
