Extended Data Fig. 10: Model describing CEN element functions in local and remote tissues.
From: Enhancer selection dictates gene expression responses in remote organs during tissue regeneration
(Top) Cardiac injury induces cebpd expression locally, regulating epicardial activation during heart regeneration. CEN is sufficient but not required for directing local cebpd induction, likely due to existence of redundant enhancers. (Bottom) Cardiac injury leads to transcriptional activation by bound corticosteroid receptors in remote tissues. CEN exists in an open, permissive structure, topologically close to its promoter and poised for corticosteroid receptor binding. Ligand-bound corticosteroid receptors trigger CEN-directed cebpd expression in distant tissues, contributing to fluid homeostasis in animals undergoing injury-induced regeneration.
