Extended Data Fig. 7: Adiponectin receptor function reduces the frequencies of splenic myeloid cells in 5-6 and 19-24 month old mice (related to Fig. 6). | Nature Cell Biology

Extended Data Fig. 7: Adiponectin receptor function reduces the frequencies of splenic myeloid cells in 5-6 and 19-24 month old mice (related to Fig. 6).

From: Adiponectin receptors sustain haematopoietic stem cells throughout adulthood by protecting them from inflammation

Extended Data Fig. 7

a-d. The frequencies of CMPs, MEPs, GMPs (a, c), differentiated T, B, myeloid, and erythroid cells (b, d) in the bone marrow from 5-6 month old (a-b) or 19-24 month old (c-d) Vav1-Cre; Adipor1fl/fl; Adipor2fl/fl or control mice (n = 7 (a-b) or n = 5 (c-d) Vav1-Cre; Adipor1fl/fl; Adipor2fl/fl mice and n = 10 (a-b) or n = 6 (c-d) control mice in two independent experiments per age group). e-n. The frequencies of HSCs (e, j), MPPs (f, k), HPCs (g, l), CMPs, MEPs, GMPs (h, m), and differentiated T, B, myeloid, and erythroid cells (i, n) in the spleens of 5–6-month-old (e-i) and 19-24 month-old (j-n) Vav1-Cre; Adipor1fl/fl; Adipor2fl/fl or control mice (n = 7 (e-i) or n = 5 (j-n) Vav1-Cre; Adipor1fl/fl; Adipor2fl/fl mice and n = 10 (e-i) or n = 6 (j-n) control mice in two independent experiments per age group). All data represent mean ± standard deviation and each dot reflects a different mouse. Statistical significance was assessed using Mann-Whitney tests followed by Holm-Sidak’s multiple comparisons adjustments (a-n). All statistical tests were two-sided. Source numerical data are available in the source data files.

Source data

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