Extended Data Fig. 1: Adiponectin receptor deficient mice are born in normal numbers and are normal in size (related to Fig. 1).
a-c. Vav1-Cre; Adipor1fl/fl; Adipor2fl/fl mice were born at the expected mendelian frequencies (a) and were grossly normal in size (b) and appearance (c) (n = 4 female and n = 8 male Vav1-Cre; Adipor1fl/fl; Adipor2fl/fl mice and n = 10 female and n = 3 male control mice in one experiment (b)). d. The number of bone marrow cells in one femur and one tibia or in the spleen of 8-10-week-old Vav1-Cre and control mice (five mice per genotype in one experiment). e. White blood cell, red blood cell, and platelet counts in the blood of 8–10-week-old Vav1-Cre and control mice (five mice per genotype in one experiment). f-i. The frequencies of HSCs (f), MPPs (g), HPCs (h), CMPs, MEPs, and GMPs (i) in bone marrow from one femur and one tibia of Vav1-Cre and control mice (five mice per genotype in one experiment). j-m. The frequencies of HSCs (j), MPPs (k), HPCs (l), CMPs, MEPs, and GMPs (m) in splenocytes from Vav1-Cre and control mice (five mice per genotype in one experiment). All data represent mean ± standard deviation and each dot reflects a different mouse. Statistical significance was assessed using Mann-Whitney tests followed by Holm-Sidak’s multiple comparisons adjustments (b and d-e) or Student’s t-tests followed by Holm-Sidak’s multiple comparisons adjustments (f-m). All statistical tests were two-sided. Source numerical data are available in the source data files.
