Extended Data Fig. 6: SOX2-ON express spinal-cord markers at low levels. | Nature Cell Biology

Extended Data Fig. 6: SOX2-ON express spinal-cord markers at low levels.

From: Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation

Extended Data Fig. 6

(a) Differentially expressed genes associated with CEpiLC specific cluster 1 CREs are enriched for biological processes underlying the patterning of the anterior-posterior axis. (b) Differentially expressed genes associated with SOX2-ON specific cluster 3 CREs are enriched for biological processes related to nervous system development. Differential expression criteria for genes analysed in A and B = FDR < 0.05 as determined by DESeq2 padj metric from n=3 biological replicates. (c) Cluster 3 associated genes with GO terms related to nervous system development from (b) that are expressed at high levels in spinal-cord (SC) neural progenitors exhibit comparatively low expression in SOX2-ON, ES cells, EpiLCs and CEpiLCs. Illustrative genes for each cluster are highlighted. Spinal cord progenitor data reanalysed from9.

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