Extended Data Fig. 3: Gene signature of CAFs and mural cells. | Nature Cell Biology

Extended Data Fig. 3: Gene signature of CAFs and mural cells.

From: A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

Extended Data Fig. 3

a, UMAP plot after re-clustering of the CAF cell type in the data set from Extended Data Fig. 2b. b, Violin plots showing the expression of the indicative CAF and melanoma markers at the CAFs subclusters and melanoma cells (large B16F10 tumours). c, Dot plot displaying selected gene markers across CAFs subclusters. d, Violin plots showing the expression of Acta2 and Pdgfrβ in CAFs subclusters. e, Bar plot displaying the normalized Log2 fold change (WT/KO) of CAFs subclusters in each genotype. f, UMAP plots of B16F10 small (top row) and large (bottom row) tumours coupled with the expression signal of the vCAFs- and mural cells-specific gene signatures.

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