Extended Data Fig. 10: Proposed model. | Nature Cell Biology

Extended Data Fig. 10: Proposed model.

From: A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

Extended Data Fig. 10

Working model for host ATF4’s role in tumour progression and metastasis. ATF4 is essential for the CAF activation via direct regulation of Col1a1 expression and by impacting multiple additional steps in the collagen synthesis pathway, including Glycine (Gly) and Proline (Pro) pools. The resulting abrogation of Collagen I (and potentially additional collagen isoforms) in ATF4-deficient FBs leads in dramatic reduction in secreted extracellular matrix collagen, which in turn results in defective CAF activation and reduced levels of angiogenic cytokine signaling to endothelial cells. The resulting defective angiogenesis leads to reduced support for primary and metastatic tumour growth.

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