Extended Data Fig. 5: The distribution of ZBTB43 affinity binding peaks closely matches predicted Z-DNA sites.
From: Z-DNA is remodelled by ZBTB43 in prospermatogonia to safeguard the germline genome and epigenome
Venn diagrams depict the location of ZBTB43 affinity peaks mapped in fully methylated genomic DNA (SssI) and unmethylated genomic DNA (TKO) relative to the location of transcripts in the genome. In comparison, the distribution of predicted Z-DNA17 and enriched Z-DNA mapped in vivo in activated B-cells18 are also depicted to the right. (a) All genomic locations are plotted. (b) Distal intergenic regions are excluded. Affinity-sequencing results represent two independent biological replicates.
