Extended Data Fig. 4: Investigation of differentiation trajectories in WT and HHEX KO cells through scRNA-seq analysis. | Nature Cell Biology

Extended Data Fig. 4: Investigation of differentiation trajectories in WT and HHEX KO cells through scRNA-seq analysis.

From: CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction

Extended Data Fig. 4

a, UMAP visualization of all Seurat clusters from experiment 2, shown with distinct colors. Clusters 1-15 were annotated as in Fig. 6b. b, UMAP visualization of the integrated data from all samples of both experiments at the DE, GT, PP1, and PP2 stages. The overlapping embedding of DE cells shows that the batch effect was removed. c, WT and KO lineages visualized by forced-directed layouts of the integrated data from the DE, GT, PP1, and PP2 stages. Cells at DE and GT stages are shown here. Data shown in a-c represent one independent experiment.

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