Extended Data Fig. 3: Stromal cell analysis across sample types. | Nature Cell Biology

Extended Data Fig. 3: Stromal cell analysis across sample types.

From: Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues

Extended Data Fig. 3

a, Bar plot representing the proportion of stromal cell types in control endometrium and endometriosis lesions. Endometrial fibroblasts were found in all lesions. Fibroblast C7 is the predominant fibroblast type in EcO. b, Density plot showing distribution of mural cells for each tissue. Arrows points to Prv-CCL19. c, Heatmap of markers genes for mural cell subtypes. d, Track plot representing gene expression pattern for selected DEG in Prv-CCL19 subpopulations. GGT5 and ABCC9 are pan-markers for this cell subtype. e, Box plot showing the proportion of CCL19-expressing cells in Prv-CCL19 subpopulation within each tissue type. Each dot represents the percentage of CCL19+ cells in a tissue biopsy (Ctrl n = 3, EuE n = 9, EcP n = 8, EcPA n = 6, EcO n = 4). The box represents the interquartile range with median and minimum/maximum represented by box centerline and whiskers, respectively. Related to Fig. 2.

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