Fig. 1: HASTER transcribes an evolutionarily conserved nuclear RNA.
From: The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A
a, Human islet RNA-seq (reads per kilobase per million reads, RPKM) and CAGE (normalized tag counts, TPM) showing overlapping and divergent transcription of HNF1A and HASTER (representative examples from four biological replicates). HASTER isoforms were detected by 3′ RACE from human islets. b, Liver strand-specific RNA-seq (RPKM) and Multiz alignments in the indicated species. c, Single-molecule fluorescence in situ hybridization for HASTER (exonic probes) and HNF1A nascent transcripts (intronic probes) in EndoC-βH3 β cells. The yellow arrows indicate co-localization of HASTER and nascent HNF1A transcripts. Quantifications are shown in Extended Data Fig. 2. Scale bar, 2 µm.
