Extended Data Fig. 4: HASTER is sensitive to decreased or increased HNF1A expression.
From: The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A
a, Locked nucleic acid (LNA) GapmeR knockdown of HNF1A (#1, HNF1A exon 8; #2, HNF1A exon 1) in human EndoC-βH3 β cells led to decreased HASTER RNA, and minor changes in other HNF1A-dependent genes. n = 3 nucleofections, TBP-normalized mean ± s.d.; two-tailed Student’s t-test. b, CRISPR-SAM activation of Hnf1a in mouse MIN6 β cells. n = 3 lentiviral transductions, representative of 2 independent experiments. Tbp-normalized mean ± s.d.; two-tailed Student’s t-test.
