Extended Data Fig. 1: HASTER and HNF1A regulatory landscapes.
From: The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A
a, Chromatin and RNA maps in mouse (top) and human islets (bottom). Human CAGE is from islets, and mouse CAGE is from pancreas. The two mouse Haster transcriptional start sites are highlighted in blue, although only one transcriptional origin is apparent in human islets. The E islet enhancer, and CTCF-bound C region, both of which are bound by islet transcription factors, are highlighted in beige. b, HNF1A and HASTER expression across GTEx human tissues (Data Source: GTEx Analysis Release V8) and human islets (n = 130). Boxes show median and interquartile ranges. c, HASTER and HNF1A median transcript levels across tissues are negatively correlated, with the exception of whole pancreas.
