Extended Data Fig. 1: LPAR4 is a stress- inducible gene.
a, Graph showing relative mRNA expression of six LPARs (normalized to housekeeping gene RPL37A) for cells grown in 10% serum and 2D. b, Graph comparing LPARs expression on cells grown in stem-like culture conditions (that is, no serum/3D) for 72 h with respect to cells grown in 10% serum on 2D for 72 h. c, Graph comparing LPARs expression on cells grown in hypoxia condition (1% O2) for 72 h with respect to cells grown in normoxia for 72 h. d, e, Graphs comparing LPARs expression on cells grown in 3D condition treated with varying doses of gemcitabine or paclitaxel for 24 h. Bars represent median value per cell line (a–c). Data were presented as mean ± s.d. for n = 3 independent experiments. Statistical analyses were performed using two tailed unpaired one sample t-test (b-e). Source numerical data are available in source data.
