Accumulation of senescent cells and compositional changes in gut microbiota have been independently reported to occur as a function of age. A study now suggests that these two seemingly disparate processes are more intimately linked than previously appreciated via a B cell–IgA–microbiota axis.
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B.G.C. and D.J.B. have a potential financial interest related to this research. They are a co-inventors on patents held by Mayo Clinic and patent applications licensed to or filed by Unity Biotechnology, and are Unity Biotechnology shareholders. Research in the Baker laboratory has been reviewed by the Mayo Clinic Conflict of Interest Review Board and is being conducted in compliance with Mayo Clinic Conflict of Interest policies. S.I.G. has no competing interests.
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Childs, B.G., Graves, S.I. & Baker, D.J. B cell senescence takes guts. Nat Cell Biol 25, 800–801 (2023). https://doi.org/10.1038/s41556-023-01153-5
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DOI: https://doi.org/10.1038/s41556-023-01153-5
