Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Perspective
  • Published:

Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

Nature Cell Biology volume 25, pages 1089–1100 (2023)Cite this article

Subjects

An Author Correction to this article was published on 01 March 2024

This article has been updated

Abstract

The Human BioMolecular Atlas Program (HuBMAP) aims to create a multi-scale spatial atlas of the healthy human body at single-cell resolution by applying advanced technologies and disseminating resources to the community. As the HuBMAP moves past its first phase, creating ontologies, protocols and pipelines, this Perspective introduces the production phase: the generation of reference spatial maps of functional tissue units across many organs from diverse populations and the creation of mapping tools and infrastructure to advance biomedical research.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Molecular coverage and spatial scale of different assay types.
Fig. 2: Organs and assay types publicly available via the HuBMAP portal (as of May 2023).
Fig. 3: Unique FTU neighbourhoods in different biological contexts in the human body.
Fig. 4: New technologies, resources, integrated knowledge base and mapping in the production phase.

Similar content being viewed by others

Code availability

The HuBMAP Consortium GitHub at https://github.com/hubmapconsortium has 120 repositories that support data ingest, analysis, visualization and search plus HRA construction and usage. Documentation is available at https://software.docs.hubmapconsortium.org/apis.html.

Change history

References

  1. Snyder, M. P. et al. The human body at cellular resolution: the NIH Human Biomolecular Atlas Program. Nature 574, 187–192 (2019).

    Article  ADS  Google Scholar 

  2. Hao, Y. et al. Integrated analysis of multimodal single-cell data. Cell 184, 3573–3587.e29 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Börner, K. et al. Anatomical structures, cell types and biomarkers of the Human Reference Atlas. Nat. Cell Biol. 23, 1117–1128 (2021).

    Article  ADS  PubMed  PubMed Central  Google Scholar 

  4. Hickey, J. W. et al. Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging. Nat. Methods 19, 284–295 (2022).

    Article  CAS  PubMed  Google Scholar 

  5. Quardokus, E. M. et al. Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging. Nat. Methods https://doi.org/10.1038/s41592-023-01846-7 (2023).

  6. Neumann, E. K. et al. A multiscale lipid and cellular atlas of the human kidney. Preprint at bioRxiv https://doi.org/10.1101/2022.04.07.487155 (2022).

  7. Ghose, S. et al. Human digital twin: automated cell type distance computation and 3D atlas construction in multiplexed skin biopsies. Preprint at bioRxiv https://doi.org/10.1101/2022.03.30.486438 (2022).

  8. Canela, V. H. et al. A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury and matrix remodeling in patients with stone disease. Nat. Commun. https://doi.org/10.1038/s41467-023-38975-8 (2023).

  9. Hickey, J. et al. High resolution single cell maps reveals distinct cell organization and function across different regions of the human intestine. Nature https://doi.org/10.1038/s41586-023-05915-x (2023).

  10. Greenbaum, S. et al. Spatiotemporal coordination at the maternal–fetal interface promotes trophoblast invasion and vascular remodeling in the first half of human pregnancy. Nature https://doi.org/10.1038/s41586-023-06298-9 (2023).

  11. Blue, B. L. et al. An atlas of healthy and injured cell states and niches in the human kidney. Nature https://doi.org/10.1038/s41586-023-05769-3 (2023).

  12. Eng, C.-H. L. et al. Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH. Nature 568, 235–239 (2019).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  13. Rodriques, S. G. et al. Slide-seq: a scalable technology for measuring genome-wide expression at high spatial resolution. Science 363, 1463–1467 (2019).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  14. Guilliams, M. et al. Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches. Cell 185, 379–396.e38 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Stelzer, E. H. K. Light-sheet fluorescence microscopy for quantitative biology. Nat. Methods 12, 23–26 (2015).

    Article  CAS  PubMed  Google Scholar 

  16. Black, S. et al. CODEX multiplexed tissue imaging with DNA-conjugated antibodies. Nat. Protoc. 16, 3802–3835 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Neumann, E. K. et al. Protocol for multimodal analysis of human kidney tissue by imaging mass spectrometry and CODEX multiplexed immunofluorescence. STAR Protoc. 2, 100747 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Spraggins, J. M. et al. High-performance molecular imaging with MALDI trapped ion-mobility time-of-flight (timsTOF) mass spectrometry. Anal. Chem. 91, 14552–14560 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Börner, K. et al. Tissue registration and exploration user interfaces in support of a human reference atlas. Commun. Biol. 5, 1369 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  20. Rozenblatt-Rosen, O. et al. The Human Tumor Atlas Network: charting tumor transitions across space and time at single-cell resolution. Cell 181, 236–249 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Rozenblatt-Rosen, O., Stubbington, M. J. T., Regev, A. & Teichmann, S. A. The Human Cell Atlas: from vision to reality. Nature 550, 451–453 (2017).

    Article  ADS  CAS  PubMed  Google Scholar 

  22. Mungall, C. J., Torniai, C., Gkoutos, G. V., Lewis, S. E. & Haendel, M. A. Uberon, an integrative multi-species anatomy ontology. Genome Biol. 13, R5 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  23. Rosse, C. & Mejino, J. L. V. A reference ontology for biomedical informatics: the Foundational Model of Anatomy. J. Biomed. Inform. 36, 478–500 (2003).

    Article  PubMed  Google Scholar 

  24. Golbreich, C., Grosjean, J. & Darmoni, S. J. The Foundational Model of Anatomy in OWL 2 and its use. Artif. Intell. Med. 57, 119–132 (2013).

    Article  PubMed  Google Scholar 

  25. Meehan, T. F. et al. Logical development of the cell ontology. BMC Bioinform. 12, 6 (2011).

    Article  Google Scholar 

  26. Eraslan, G. et al. Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function. Science 376, eabl4290 (2022).

  27. de Boer, I. H. et al. Rationale and design of the Kidney Precision Medicine Project. Kidney Int. 99, 496–510 (2021).

    Article  Google Scholar 

  28. Manz, T. et al. Viv: multiscale visualization of high-resolution multiplexed bioimaging data on the web. Nat. Methods 19, 515–516 (2022).

  29. Lee, P. J. et al. NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health. Nat. Aging 2, 1090–1100 (2022).

    Article  Google Scholar 

  30. Keren, L. et al. MIBI-TOF: a multiplexed imaging platform relates cellular phenotypes and tissue structure. Sci. Adv. 5, eaax5851 (2019).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  31. He, S. et al. High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging. Nat. Biotechnol. 40, 1794–1806 (2022).

    Article  CAS  PubMed  Google Scholar 

  32. Tian, H. et al. Successive high-resolution (H2O)n-GCIB and C60-SIMS imaging integrates multi-omics in different cell types in breast cancer tissue. Anal. Chem. 93, 8143–8151 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Xu, T.-Y., Calandrelli, R., Lin, P., Zhu, D. & Zhong, S. HiFi-Slide spatial RNA-sequencing. Protocol.io https://doi.org/10.17504/protocols.io.3byl4by18vo5/v1 (2022).

  34. Fung, A. A. & Shi, L. Mammalian cell and tissue imaging using Raman and coherent Raman microscopy. Wiley Interdiscip. Rev. Syst. Biol. Med. 12, e1501 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  35. Zhang, W. et al. Multi-molecular hyperspectral PRM-SRS imaging. Preprint at bioRxiv https://doi.org/10.1101/2022.07.25.501472 (2022).

  36. Balaratnasingam, C. et al. Histologic and optical coherence tomographic correlates in drusenoid pigment epithelium detachment in age-related macular degeneration. Ophthalmology 124, 644–656 (2017).

    Article  PubMed  Google Scholar 

  37. Spaide, R. F. & Curcio, C. A. Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model. Retina 31, 1609 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  38. Zhu, Y. et al. Nanodroplet processing platform for deep and quantitative proteome profiling of 10–100 mammalian cells. Nat. Commun. 9, 882 (2018).

    Article  ADS  PubMed  PubMed Central  Google Scholar 

  39. Ardini-Poleske, M. E. et al. LungMAP: the molecular atlas of lung development program. Am. J. Physiol. Lung Cell. Mol. Physiol. 313, L733–L740 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  40. Uhlén, M. et al. Tissue-based map of the human proteome. Science 347, 1260419 (2015).

    Article  PubMed  Google Scholar 

  41. Lonsdale, J. et al. The Genotype-Tissue Expression (GTEx) project. Nat. Genet. 45, 580–585 (2013).

    Article  CAS  Google Scholar 

  42. Brbić, M. et al. Annotation of spatially resolved single-cell data with STELLAR. Nat. Methods 19, 1411–1418 (2022).

    Article  PubMed  Google Scholar 

  43. Govind, D. et al. PodoSighter: A cloud-based tool for label-free podocyte detection in kidney whole-slide images. J. Am. Soc. Nephrol. 32, 2795–2813 (2021).

  44. Lutnick, B. et al. A user-friendly tool for cloud-based whole slide image segmentation with examples from renal histopathology. Commun. Med. 2, 105–109 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  45. Van de Plas, R., Yang, J., Spraggins, J. & Caprioli, R. M. Image fusion of mass spectrometry and microscopy: a multimodality paradigm for molecular tissue mapping. Nat. Methods 12, 366–372 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  46. Tideman, L. E. M. et al. Automated biomarker candidate discovery in imaging mass spectrometry data through spatially localized Shapley additive explanations. Anal. Chim. Acta 1177, 338522 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Weber, G. M., Ju, Y. & Börner, K. Considerations for using the vasculature as a coordinate system to map all the cells in the human body. Front. Cardiovasc. Med. 7, 29 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  48. Melani, R. D. et al. The Blood Proteoform Atlas: a reference map of proteoforms in human hematopoietic cells. Science 375, 411–418 (2022).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  49. Mackenzie, N. J. et al. Modelling the tumor immune microenvironment for precision immunotherapy. Clin. Transl. Immunol. 11, e1400 (2022).

    Article  CAS  Google Scholar 

  50. Becker, W. R. et al. Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer. Nat. Genet. 54, 985–995 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Wallace, D. C. Mitochondrial DNA variation in human radiation and disease. Cell 163, 33–38 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Wallace, D. C. Mitochondrial genetic medicine. Nat. Genet. 50, 1642–1649 (2018).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We thank L. M. McGuire, SciStories, F. Goncalves, H. Schlehlein and V. A. Deshpande for their efforts in designing and creating graphics. We thank A. Honkala for assistance with manuscript formatting. We thank Z. Galis from the National Heart, Lung, and Blood Institute for many useful comments. Support for title page creation and format was provided by AuthorArranger, a tool developed at the National Cancer Institute. The authors gratefully acknowledge NIH HuBMAP grants U54HL165442 and U01HL166058 (L.P.); U54DK134301 and OT2OD033753 (S.J.); U54EY032442, U54DK120058 and U54DK134302 (J.M.S.); OT2OD033756 and OT2OD026671 (K.B.); UH3CA246635 (N.L.K.); UG3CA256967 (H.L.); U54HG010426 (M.P.S.); UH3CA246633 (M.A.); U54HD104393 (L.C.L. and P.R.); U54DK127823 (E.S.N., J.P.C. and W.-J.Q.); OT2OD033758 (N.G.); UH3CA246594 (F.G.); U54EY032442 and U54DK134302 (J.P.G.); U54HL145611 (S.L. and Y.L.); U01HG012680 (A.N.); U54DK120058, U54EY032442 and U54DK134302 (B.R.S.); UG3CA256959 (M.Z.); and U54HL165440 (I.S.V.). The authors are also supported by these grants: 2U01DK114933, P50DK133943 and U24DK135157 (S.J.); U54HL145608 and U54HL165443 (J.S.H.); U24CA268108 and U2CDK114886 (K.B.); Department of Defense W81XWH-22-1-0058 and Additional Ventures (L.P.). J.W.H. was supported by an NIH T32 Fellowship (T32CA196585) and an American Cancer Society: Roaring Fork Valley Postdoctoral Fellowship (PF-20-032-01-CSM). This work was supported, in part, by the Intramural Research Program of the NIH, National Institute of Allergy and Infectious Diseases (NIAID) and National Cancer Institute (NCI) (A.J.R.).

Author information

Author notes

  1. These authors contributed equally: Sanjay Jain, Liming Pei, Jeffrey M. Spraggins, Katy Börner, Michael P. Snyder.

Authors and Affiliations

  1. Department of Medicine, Washington University School of Medicine, St Louis, MO, USA

    Sanjay Jain, Kristin Conlon, Reetika R. Ghag, Madhurima Kaushal, Amanda Knoten, Praveen Krishnamoorthy, Brittany Minor, Gerald Nwanne, Diane Salamon & Bo Zhang

  2. Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA

    Sanjay Jain

  3. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA

    Sanjay Jain & Joseph P. Gaut

  4. Center for Mitochondrial and Epigenomic Medicine, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Liming Pei, Alessia Angelin, Jeff Haltom, Eric Kutschera, Chunjie Liu, Marie Lott, Peiran Lu, Ting Peng, Douglas Wallace, Yi Xing & Shiping Zhang

  5. Department of Cell and Developmental Biology and the Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA

    Jeffrey M. Spraggins, Jamie Allen, Madeline E. Colley, Martin Dufresne, Olof Gerdur Isberg, Audra Judd, Angela R. S. Kruse, Morad Malek, Ellie Pingry, David Reeves, Tina Tsui & Ali Zahraei

  6. Department of Pathology, Stanford School of Medicine, Stanford, CA, USA

    Michael Angelo

  7. Texas Advanced Computing Center, University of Texas at Austin, Austin, TX, USA

    James P. Carson

  8. Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA

    Nils Gehlenborg, Lisa Choy, John Conroy, Ilan Gold, Mark Keller, Peter Kharchenko, Tiffany Liaw, Trevor Manz, Chuck McCallum, Eric Moerth, Tram Nguyen, Morla-Adames Roselkis, Thomas Smits & Morgan Turner

  9. GE Research Center, Niskayuna, NY, USA

    Fiona Ginty, Chrystal Chadwick, Sanghee Cho, Soumya Ghose, Lisa Lowery, Elizabeth McDonough, Liz McDonough & Christine Surrette

  10. Department of Intelligent Systems, Delft University of Technology, Delft, Netherlands

    Joana P. Gonçalves & Roger Moens

  11. Department of Pediatrics (Pulmonology) and Program for Rare and Interstitial Lung Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    James S. Hagood

  12. Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA

    John W. Hickey

  13. Departments of Medicine, Chemistry and Molecular Biosciences, Northwestern University, Evanston, IL, USA

    Neil L. Kelleher, Michael Caldwell, Nathaniel Henning & Pei Su

  14. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA

    Louise C. Laurent, Kathleen Fisch, Molly Huang, Marni Jacobs, Scott Lindsay, Cayla Mason, Morgan Meads, Chanond Nasamran, Mana Parast, Rebecca Rakow-Penner, Ana Rodríguez-Soto & Valentina Stanley

  15. Division of Cardiology, University of Washington School of Medicine, Seattle, WA, USA

    Shin Lin, Dana Jackson & David Read

  16. Department of Surgery, Washington University School of Medicine, St Louis, MO, USA

    Yiing Lin

  17. Departments of Pharmacology, Medicine (Hematology and Oncology), Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Huiping Liu, Constadina Arvanitis, David Scholten & Jian-Jun Wei

  18. Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, USA

    Alexandra Naba & Yu Gao

  19. Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA

    Ernesto S. Nakayasu, Wei-Jun Qian, Geremy Clair, Yumi Kwon, Matthew Monroe & Ying Zhu

  20. Lymphocyte Biology Section and Center for Advanced Tissue Imaging, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA

    Andrea Radtke

  21. The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA

    Paul Robson, Elise Courtois, William F. Flynn, Ramalakshmi Ramasamy & Santhosh Sivajothi

  22. Department of Biological Sciences and Department of Chemistry, Columbia University, New York, NY, USA

    Brent R. Stockwell, Aubrianna Decker, Taruna Neelakantan & Presha Rajbhandari

  23. Delft Center for Systems and Control, Delft University of Technology, Delft, Netherlands

    Raf Van de Plas, Lukasz G. Migas & Leonoor Tideman

  24. Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Ioannis S. Vlachos

  25. Spatial Technologies Unit, Harvard Medical School Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA

    Ioannis S. Vlachos

  26. Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, USA

    Mowei Zhou, Christopher R. Anderton, Lisa Bramer, Kristin Burnum-Johnson, David Degnan, James Fulcher, Brittney Gorman, Reta Birhanu Kitata, Yen-Chen Liao, Ljiljana Pasa-Tolic, Paul Piehowski, Tujin Shi, Chia-Feng Tsai, Dusan Velickovic, Marija Velickovic & Kevin Zemaitis

  27. Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA

    Katy Börner

  28. Department of Genetics, Stanford School of Medicine, Stanford, CA, USA

    Michael P. Snyder

  29. Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA

    Kyung Jin Ahn, Huajun Bai, Po Hu, Danika Makowski, Riley Sawka & Kai Tan

  30. Department of Biochemistry and the Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA

    David M. Anderson, Richard Caprioli, Melissa A. Farrow, Nathan Heath Patterson & Kevin Schey

  31. University of Alabama at Birmingham, Birmingham, AL, USA

    Christine Curcio, Dongfeng Cao & Jeffrey Messinger

  32. Johns Hopkins University, Baltimore, MD, USA

    Lyla Atta, Carla Dodd, Rafael dos Santos Peixoto, Jean Fan, Marc Halushka, Kyu Sang Han, Brendan Miller, Fan Wu & Pei-Hsun Wu

  33. The University of Texas at Austin, Austin, TX, USA

    Demi Awosika-Olumo & Ari Kahn

  34. Stanford University, Stanford, CA, USA

    Amir Bahmani, Laren Becker, Winston Becker, Sean Bendall, Keith Bettinger, Marc Bosse, Eugene Butcher, Chiara Caraccio, Derek Chen, Kevin Contrepois, Daniel Cotter, Tushar Desai, Almudena Espin-Perez, Edward D. Esplin, Patricia Favaro, Ferda Filiz, William Greenleaf, Noah Greenwald, Casey Hanson, Pehr Harbury, Josef Hardi, Lihua Jiang, Adam Kagel, Thomas Karathanos, Anshul Kundaje, Samuel Lancaster, Hayan Lee, Jennifer Li, Emma Monte, Mark A. Musen, Stephanie Nevins, Garry Nolan, Martin O’Connor, Mina Pichavant, Sylvia Plevritis, Xiaotao Shen, Albert G. Tsai, Jason Tung, Sricharan Reddy Varra, Meng Wang, Bei Wei, Annika Weimer, Bingqing Zhao, Bokai Zhu & Chenchen Zhu

  35. Broad Institute, Boston, MA, USA

    Karol Balderrama, Fei Chen, Gokcen Eraslan, Katelyn Flowers, Jonah Langlieb, Jilong Li, Evan Macosko, Evan Murray, Nina Sachdev, Eeshit Dhaval Vaishnav & James Webber

  36. University of Florida, Gainesville, FL, USA

    Leandro Balzano, Samuel Border, Maigan Brusko, Elizabeth Butterworth, Martha Campbell-Thompson, Jing Chen, Jamie Fermin, Dongtao (Ann) Fu, Hunter Hakimian, Linda Harlan, David Jewell, Suhas Katari, Heather Kates, Jessica Kirwan, Yulia Levites Strekalova, Nicholas Lucarelli, David Manthey, Clayton Mathews, Miguel Medina-Serpas, Sayat Mimar, Ahmed Naglah, Pinaki Sarder, Clive Wasserfall, Leonard Wayne & MacKenzie Williams

  37. University of Rochester Medical Center, Rochester, NY, USA

    Gautam Bandyopadhyay, Anthony Corbett, Jennifer Dutra, Jeanne Holden-Wiltse, Heidie Huyck, Ravi Misra & Gloria Pryhuber

  38. University of Pennsylvania, Philadelphia, PA, USA

    Shovik Bandyopadhyay, Kurt Barnhart, Kenneth Bedi, Michael Duffy, Stephen Fisher, James Gee, Brian Gregory, Rong Guo, Tamjid Imtiaz, Maxim Itkin, Sarah Johnston, Junhyong Kim, Kuang Da, Yulieh Lin, Kenneth Margulies, Hieu Nguyen, Kathleen O’Neill, Minxing Pang, Alison Pouch, Ling Qin, Jean Rosario, Lauren Schwartz, Michal Silber, Kathleen Thomas, Tracey Thomas & Abashai Woodard

  39. Carnegie Mellon University, Pittsburgh, PA, USA

    Ziv Bar-Joseph, Haoran Chen, Monica Dayao, Sean Donahue, Carl Kingsford, Vladimir Kiselev, Dongshunyi Li, Xinyue Lu, Jian Ma, Bob (Robert) Murphy, Nam Nguyen, Allyson Ricarte, Matt Ruffalo, Sarah Schultz, Qi Song, Vasyl Vaskivskyi, Zishen Wen & Ted Zhang

  40. Indiana University, Indianapolis, IN, USA

    Daria Barwinska, Michael T. Eadon, Tarek M. El-Achkar, Debora Gisch, Ricardo Melo Ferreira & Angela Sabo

  41. University of Pittsburgh, Pittsburgh, PA, USA

    Michael Becich, Karl Burke, Aaron Cruz, Louis Falo, Derek Furst, Jesse Helfer, Arivarasan Karunamurthy, Charles Kollar, Kay Metis, Melissa Schwenk, Bill Shirey, Max Sibilla, Alan Simmons, Hua Tian, Jessica Waldrip & Zhou Yuan

  42. PSC (Pittsburgh Supercomputing Center)/CMU, Pittsburgh, PA, USA

    Kathy Benninger, David Betancur, Sunteasja Billings, Philip Blood, Ivan Cao-Berg, Megan Carroll, Kenneth Chiacchia, Christopher Csonka, Stephen Deems, Michelle Devlin, Diane Eshelman, Shane Filus, Brendan Honick, Greg Hood, Mariah Kenney, Deb Nigra, Gesina Phillips, Juan Puerto, Alexander Ropelewski, Robin Scibek, Holly Shephard, Jonathan Silverstein, Derek Simmel, Marissa Thompson, Jackie Uranic & Joel Welling

  43. Indiana University, Bloomington, IN, USA

    Daniel Bolin, Andreas Bueckle, Vicky Daiya, Shakeel Ahamed Davanagere, Vikrant Deshpande, Michael Gallant, Aashay Gondalia, Bruce W. Herr II, Yashvardhan Jain, Yingnan Ju, Libby Maier, Matthew Martindale, Danial Qaurooni, Ellen M. Quardokus, Elizabeth G. Record, Nancy Ruschman, Heidi Schlehlein, Abhiroop Tejomay & Devin Wright

  44. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

    Maya Brewer, Kelly A. Clouthier, Mark P. de Caestecker, Raymond C. Harris & Diane Saunders

  45. California Institute of Technology, Pasadena, CA, USA

    Long Cai, Dinh Diep, Xuefei Wang & Chi (Jina) Yun

  46. University of California San Diego, San Diego, CA, USA

    Riccardo Calandrelli, Dinh Diep, Thu Elizabeth Duong, Anthony Fung, Kyle Gaulton, Kian Kalhor, Colin Kern, Blue B. Lake, Zhi Li, Pei Lin, Yuan Liu, Zhifei Luo, Tri Nguyen, Lingyan Shi, Francesca Soncin, Xin Sun, Jamie Verheyden, Xueyi Wan, Allen Wang, Xingzhao Wen, Qiuyang Wu, Tianyang Xu, Chi Zhang, Kun Zhang, Wenxin Zhao, Sheng Zhong, Diming Zhu & Quan Zhu

  47. European Bioinformatics Institute, Hinxton, UK

    Anita Caron & John Marioni

  48. Beth Israel Deaconess Medical Center, Boston, MA, USA

    Angela Chen, Zhenghui G. Jiang, Nikolaos Kalavros, Dimitra Karagkouni, Christopher Mistretta, Nancy Otaluka, Yered Pita-Juarez, Athanasios Ploumakis, Dhruv Singhal, Leo Tsai, Shuoshuo Wang & Joseph Yap

  49. University of Connecticut/Scripps, Mansfield, USA

    Li Chen, Merissa Olmer, David Rowe, Dong-Guk Shin, Hannah Swahn, Caibin Zhang & Chenyu Zhang

  50. Stony Brook University, Stony Brook, NY, USA

    Lu Chen & Fusheng Wang

  51. Marquette University, Milwaukee, WI, USA

    Peter Chou & David Helminiak

  52. University of California Santa Cruz, Santa Cruz, CA, USA

    Cecilia Cisar, Kimberley Czupil, Nicholas Keener, Benedict Paten & Walter Shands

  53. New York Genome Center, New York City, NY, USA

    Laura Clarke, Shila Ghazanfar, Austin Hartman, Alsu Missarova, Gesmira Molla, Mike Morgan, Rahul Satija & Tim Stuart

  54. GE Research Cente, Niskayuna, NY, USA

    Alex Corwin

  55. Native BioData Consortium, Oklahoma City, OK, USA

    Kali Dale

  56. University of Washington, Seattle, WA, USA

    Gail Deutsch, Hannah Pilner, Jay Shendure & Cole Trapnell

  57. Altos Labs, San Diego Institute of Science, San Diego, CA, USA

    Dinh Diep, Blue B. Lake & Kun Zhang

  58. Harvard Medical School, Boston, MA, USA

    Weixiu Dong, Rajat Gupta, Martin Hemberg, Qiwen Hu, Xiaokang Lun, Mayank Mahajan, Michel Nofal, Ayellet Segre, Griffin M. Weber, Yida Zhang & Jia Wen Zheng

  59. Yale University, New Haven, CT, USA

    Archibald Enninful, Rong Fan, Negin Farzad, Fu Gao, Yang Liu, George Tellides & Mingyu Yang

  60. Department of Chemistry, Vanderbilt University, Nashville, TN, USA

    Allison Esselman

  61. Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA

    Louis D. Falo & Jonhan Ho

  62. University of Cambridge, Cambridge, UK

    Eyal Fisher

  63. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA

    Agnes B. Fogo

  64. University of Zurich, Zurich, Switzerland

    Elyas Heidari

  65. University of Connecticut, Mansfield, CT, USA

    Seung-Hyun Hong, Pujan Joshi, Mejeong Lee, Martin Lotz & Peter Maye

  66. University of Southern California, Los Angeles, CA, USA

    Young-Kwon Hong & Maria Lee

  67. Harvard University, Boston, MA, USA

    Jocelyn Kishi, Sinem Saka, Hiroshi Sasaki, Matthew Serrata, Hanquan Su & Peng Yin

  68. Delft University of Technology, Delft, Netherlands

    Roy Lardenoije

  69. Lurie Children’s Hospital, Chicago, IL, USA

    Monica Laronda & Elizabeth Tsui

  70. Purdue University, Purdue, IN, USA

    Julia Laskin, Xiangtang Li, Manxi Yang & Dong Hye Ye

  71. Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA

    Ken Lau

  72. Northwestern University, Chicago, IL, USA

    Hannah Mcdowell

  73. Boston Children’s Hospital, Boston, MA, USA

    Jeffrey Moffitt

  74. Wellcome Sanger Institute, Hinxton, UK

    Daniele Muraro & Sarah Teichmann

  75. University of North Carolina, Chapel Hill, NC, USA

    Kenichi Okuda

  76. University of Iowa, Iowa City, IA, USA

    Tarun Kanti Roy & Xiaodong Wu

  77. University of Nebraska Medical Center, Omaha, NE, USA

    Seth Winfree

  78. Pennsylvania State University, State College, PA, USA

    Nicholas Winograd

Authors
  1. Sanjay Jain
    View author publications

    Search author on:PubMed Google Scholar

  2. Liming Pei
    View author publications

    Search author on:PubMed Google Scholar

  3. Jeffrey M. Spraggins
    View author publications

    Search author on:PubMed Google Scholar

  4. Michael Angelo
    View author publications

    Search author on:PubMed Google Scholar

  5. James P. Carson
    View author publications

    Search author on:PubMed Google Scholar

  6. Nils Gehlenborg
    View author publications

    Search author on:PubMed Google Scholar

  7. Fiona Ginty
    View author publications

    Search author on:PubMed Google Scholar

  8. Joana P. Gonçalves
    View author publications

    Search author on:PubMed Google Scholar

  9. James S. Hagood
    View author publications

    Search author on:PubMed Google Scholar

  10. John W. Hickey
    View author publications

    Search author on:PubMed Google Scholar

  11. Neil L. Kelleher
    View author publications

    Search author on:PubMed Google Scholar

  12. Louise C. Laurent
    View author publications

    Search author on:PubMed Google Scholar

  13. Shin Lin
    View author publications

    Search author on:PubMed Google Scholar

  14. Yiing Lin
    View author publications

    Search author on:PubMed Google Scholar

  15. Huiping Liu
    View author publications

    Search author on:PubMed Google Scholar

  16. Alexandra Naba
    View author publications

    Search author on:PubMed Google Scholar

  17. Ernesto S. Nakayasu
    View author publications

    Search author on:PubMed Google Scholar

  18. Wei-Jun Qian
    View author publications

    Search author on:PubMed Google Scholar

  19. Andrea Radtke
    View author publications

    Search author on:PubMed Google Scholar

  20. Paul Robson
    View author publications

    Search author on:PubMed Google Scholar

  21. Brent R. Stockwell
    View author publications

    Search author on:PubMed Google Scholar

  22. Raf Van de Plas
    View author publications

    Search author on:PubMed Google Scholar

  23. Ioannis S. Vlachos
    View author publications

    Search author on:PubMed Google Scholar

  24. Mowei Zhou
    View author publications

    Search author on:PubMed Google Scholar

  25. Katy Börner
    View author publications

    Search author on:PubMed Google Scholar

  26. Michael P. Snyder
    View author publications

    Search author on:PubMed Google Scholar

Consortia

HuBMAP Consortium

  • Kyung Jin Ahn
  • , Jamie Allen
  • , David M. Anderson
  • , Christopher R. Anderton
  • , Christine Curcio
  • , Alessia Angelin
  • , Constadina Arvanitis
  • , Lyla Atta
  • , Demi Awosika-Olumo
  • , Amir Bahmani
  • , Huajun Bai
  • , Karol Balderrama
  • , Leandro Balzano
  • , Gautam Bandyopadhyay
  • , Shovik Bandyopadhyay
  • , Ziv Bar-Joseph
  • , Kurt Barnhart
  • , Daria Barwinska
  • , Michael Becich
  • , Laren Becker
  • , Winston Becker
  • , Kenneth Bedi
  • , Sean Bendall
  • , Kathy Benninger
  • , David Betancur
  • , Keith Bettinger
  • , Sunteasja Billings
  • , Philip Blood
  • , Daniel Bolin
  • , Samuel Border
  • , Marc Bosse
  • , Lisa Bramer
  • , Maya Brewer
  • , Maigan Brusko
  • , Andreas Bueckle
  • , Karl Burke
  • , Kristin Burnum-Johnson
  • , Eugene Butcher
  • , Elizabeth Butterworth
  • , Long Cai
  • , Riccardo Calandrelli
  • , Michael Caldwell
  • , Martha Campbell-Thompson
  • , Dongfeng Cao
  • , Ivan Cao-Berg
  • , Richard Caprioli
  • , Chiara Caraccio
  • , Anita Caron
  • , Megan Carroll
  • , Chrystal Chadwick
  • , Angela Chen
  • , Derek Chen
  • , Fei Chen
  • , Haoran Chen
  • , Jing Chen
  • , Li Chen
  • , Lu Chen
  • , Kenneth Chiacchia
  • , Sanghee Cho
  • , Peter Chou
  • , Lisa Choy
  • , Cecilia Cisar
  • , Geremy Clair
  • , Laura Clarke
  • , Kelly A. Clouthier
  • , Madeline E. Colley
  • , Kristin Conlon
  • , John Conroy
  • , Kevin Contrepois
  • , Anthony Corbett
  • , Alex Corwin
  • , Daniel Cotter
  • , Elise Courtois
  • , Aaron Cruz
  • , Christopher Csonka
  • , Kimberley Czupil
  • , Vicky Daiya
  • , Kali Dale
  • , Shakeel Ahamed Davanagere
  • , Monica Dayao
  • , Mark P. de Caestecker
  • , Aubrianna Decker
  • , Stephen Deems
  • , David Degnan
  • , Tushar Desai
  • , Vikrant Deshpande
  • , Gail Deutsch
  • , Michelle Devlin
  • , Dinh Diep
  • , Carla Dodd
  • , Sean Donahue
  • , Weixiu Dong
  • , Rafael dos Santos Peixoto
  • , Michael Duffy
  • , Martin Dufresne
  • , Thu Elizabeth Duong
  • , Jennifer Dutra
  • , Michael T. Eadon
  • , Tarek M. El-Achkar
  • , Archibald Enninful
  • , Gokcen Eraslan
  • , Diane Eshelman
  • , Almudena Espin-Perez
  • , Edward D. Esplin
  • , Allison Esselman
  • , Louis D. Falo
  • , Louis Falo
  • , Jean Fan
  • , Rong Fan
  • , Melissa A. Farrow
  • , Negin Farzad
  • , Patricia Favaro
  • , Jamie Fermin
  • , Ferda Filiz
  • , Shane Filus
  • , Kathleen Fisch
  • , Eyal Fisher
  • , Stephen Fisher
  • , Katelyn Flowers
  • , William F. Flynn
  • , Agnes B. Fogo
  • , Dongtao (Ann) Fu
  • , James Fulcher
  • , Anthony Fung
  • , Derek Furst
  • , Michael Gallant
  • , Fu Gao
  • , Yu Gao
  • , Kyle Gaulton
  • , Joseph P. Gaut
  • , James Gee
  • , Reetika R. Ghag
  • , Shila Ghazanfar
  • , Soumya Ghose
  • , Debora Gisch
  • , Ilan Gold
  • , Aashay Gondalia
  • , Brittney Gorman
  • , William Greenleaf
  • , Noah Greenwald
  • , Brian Gregory
  • , Rong Guo
  • , Rajat Gupta
  • , Hunter Hakimian
  • , Jeff Haltom
  • , Marc Halushka
  • , Kyu Sang Han
  • , Casey Hanson
  • , Pehr Harbury
  • , Josef Hardi
  • , Linda Harlan
  • , Raymond C. Harris
  • , Austin Hartman
  • , Elyas Heidari
  • , Jesse Helfer
  • , David Helminiak
  • , Martin Hemberg
  • , Nathaniel Henning
  • , Bruce W. Herr II
  • , Jonhan Ho
  • , Jeanne Holden-Wiltse
  • , Seung-Hyun Hong
  • , Young-Kwon Hong
  • , Brendan Honick
  • , Greg Hood
  • , Po Hu
  • , Qiwen Hu
  • , Molly Huang
  • , Heidie Huyck
  • , Tamjid Imtiaz
  • , Olof Gerdur Isberg
  • , Maxim Itkin
  • , Dana Jackson
  • , Marni Jacobs
  • , Yashvardhan Jain
  • , David Jewell
  • , Lihua Jiang
  • , Zhenghui G. Jiang
  • , Sarah Johnston
  • , Pujan Joshi
  • , Yingnan Ju
  • , Audra Judd
  • , Adam Kagel
  • , Ari Kahn
  • , Nikolaos Kalavros
  • , Kian Kalhor
  • , Dimitra Karagkouni
  • , Thomas Karathanos
  • , Arivarasan Karunamurthy
  • , Suhas Katari
  • , Heather Kates
  • , Madhurima Kaushal
  • , Nicholas Keener
  • , Mark Keller
  • , Mariah Kenney
  • , Colin Kern
  • , Peter Kharchenko
  • , Junhyong Kim
  • , Carl Kingsford
  • , Jessica Kirwan
  • , Vladimir Kiselev
  • , Jocelyn Kishi
  • , Reta Birhanu Kitata
  • , Amanda Knoten
  • , Charles Kollar
  • , Praveen Krishnamoorthy
  • , Angela R. S. Kruse
  • , Kuang Da
  • , Anshul Kundaje
  • , Eric Kutschera
  • , Yumi Kwon
  • , Blue B. Lake
  • , Samuel Lancaster
  • , Jonah Langlieb
  • , Roy Lardenoije
  • , Monica Laronda
  • , Julia Laskin
  • , Ken Lau
  • , Hayan Lee
  • , Maria Lee
  • , Mejeong Lee
  • , Yulia Levites Strekalova
  • , Dongshunyi Li
  • , Jennifer Li
  • , Jilong Li
  • , Xiangtang Li
  • , Zhi Li
  • , Yen-Chen Liao
  • , Tiffany Liaw
  • , Pei Lin
  • , Yulieh Lin
  • , Scott Lindsay
  • , Chunjie Liu
  • , Yang Liu
  • , Yuan Liu
  • , Marie Lott
  • , Martin Lotz
  • , Lisa Lowery
  • , Peiran Lu
  • , Xinyue Lu
  • , Nicholas Lucarelli
  • , Xiaokang Lun
  • , Zhifei Luo
  • , Jian Ma
  • , Evan Macosko
  • , Mayank Mahajan
  • , Libby Maier
  • , Danika Makowski
  • , Morad Malek
  • , David Manthey
  • , Trevor Manz
  • , Kenneth Margulies
  • , John Marioni
  • , Matthew Martindale
  • , Cayla Mason
  • , Clayton Mathews
  • , Peter Maye
  • , Chuck McCallum
  • , Elizabeth McDonough
  • , Liz McDonough
  • , Hannah Mcdowell
  • , Morgan Meads
  • , Miguel Medina-Serpas
  • , Ricardo Melo Ferreira
  • , Jeffrey Messinger
  • , Kay Metis
  • , Lukasz G. Migas
  • , Brendan Miller
  • , Sayat Mimar
  • , Brittany Minor
  • , Ravi Misra
  • , Alsu Missarova
  • , Christopher Mistretta
  • , Roger Moens
  • , Eric Moerth
  • , Jeffrey Moffitt
  • , Gesmira Molla
  • , Matthew Monroe
  • , Emma Monte
  • , Mike Morgan
  • , Daniele Muraro
  • , Bob (Robert) Murphy
  • , Evan Murray
  • , Mark A. Musen
  • , Ahmed Naglah
  • , Chanond Nasamran
  • , Taruna Neelakantan
  • , Stephanie Nevins
  • , Hieu Nguyen
  • , Nam Nguyen
  • , Tram Nguyen
  • , Tri Nguyen
  • , Deb Nigra
  • , Michel Nofal
  • , Garry Nolan
  • , Gerald Nwanne
  • , Martin O’Connor
  • , Kenichi Okuda
  • , Merissa Olmer
  • , Kathleen O’Neill
  • , Nancy Otaluka
  • , Minxing Pang
  • , Mana Parast
  • , Ljiljana Pasa-Tolic
  • , Benedict Paten
  • , Nathan Heath Patterson
  • , Ting Peng
  • , Gesina Phillips
  • , Mina Pichavant
  • , Paul Piehowski
  • , Hannah Pilner
  • , Ellie Pingry
  • , Yered Pita-Juarez
  • , Sylvia Plevritis
  • , Athanasios Ploumakis
  • , Alison Pouch
  • , Gloria Pryhuber
  • , Juan Puerto
  • , Danial Qaurooni
  • , Ling Qin
  • , Ellen M. Quardokus
  • , Presha Rajbhandari
  • , Rebecca Rakow-Penner
  • , Ramalakshmi Ramasamy
  • , David Read
  • , Elizabeth G. Record
  • , David Reeves
  • , Allyson Ricarte
  • , Ana Rodríguez-Soto
  • , Alexander Ropelewski
  • , Jean Rosario
  • , Morla-Adames Roselkis
  • , David Rowe
  • , Tarun Kanti Roy
  • , Matt Ruffalo
  • , Nancy Ruschman
  • , Angela Sabo
  • , Nina Sachdev
  • , Sinem Saka
  • , Diane Salamon
  • , Pinaki Sarder
  • , Hiroshi Sasaki
  • , Rahul Satija
  • , Diane Saunders
  • , Riley Sawka
  • , Kevin Schey
  • , Heidi Schlehlein
  • , David Scholten
  • , Sarah Schultz
  • , Lauren Schwartz
  • , Melissa Schwenk
  • , Robin Scibek
  • , Ayellet Segre
  • , Matthew Serrata
  • , Walter Shands
  • , Xiaotao Shen
  • , Jay Shendure
  • , Holly Shephard
  • , Lingyan Shi
  • , Tujin Shi
  • , Dong-Guk Shin
  • , Bill Shirey
  • , Max Sibilla
  • , Michal Silber
  • , Jonathan Silverstein
  • , Derek Simmel
  • , Alan Simmons
  • , Dhruv Singhal
  • , Santhosh Sivajothi
  • , Thomas Smits
  • , Francesca Soncin
  • , Qi Song
  • , Valentina Stanley
  • , Tim Stuart
  • , Hanquan Su
  • , Pei Su
  • , Xin Sun
  • , Christine Surrette
  • , Hannah Swahn
  • , Kai Tan
  • , Sarah Teichmann
  • , Abhiroop Tejomay
  • , George Tellides
  • , Kathleen Thomas
  • , Tracey Thomas
  • , Marissa Thompson
  • , Hua Tian
  • , Leonoor Tideman
  • , Cole Trapnell
  • , Albert G. Tsai
  • , Chia-Feng Tsai
  • , Leo Tsai
  • , Elizabeth Tsui
  • , Tina Tsui
  • , Jason Tung
  • , Morgan Turner
  • , Jackie Uranic
  • , Eeshit Dhaval Vaishnav
  • , Sricharan Reddy Varra
  • , Vasyl Vaskivskyi
  • , Dusan Velickovic
  • , Marija Velickovic
  • , Jamie Verheyden
  • , Jessica Waldrip
  • , Douglas Wallace
  • , Xueyi Wan
  • , Allen Wang
  • , Fusheng Wang
  • , Meng Wang
  • , Shuoshuo Wang
  • , Xuefei Wang
  • , Clive Wasserfall
  • , Leonard Wayne
  • , James Webber
  • , Griffin M. Weber
  • , Bei Wei
  • , Jian-Jun Wei
  • , Annika Weimer
  • , Joel Welling
  • , Xingzhao Wen
  • , Zishen Wen
  • , MacKenzie Williams
  • , Seth Winfree
  • , Nicholas Winograd
  • , Abashai Woodard
  • , Devin Wright
  • , Fan Wu
  • , Pei-Hsun Wu
  • , Qiuyang Wu
  • , Xiaodong Wu
  • , Yi Xing
  • , Tianyang Xu
  • , Manxi Yang
  • , Mingyu Yang
  • , Joseph Yap
  • , Dong Hye Ye
  • , Peng Yin
  • , Zhou Yuan
  • , Chi (Jina) Yun
  • , Ali Zahraei
  • , Kevin Zemaitis
  • , Bo Zhang
  • , Caibin Zhang
  • , Chenyu Zhang
  • , Chi Zhang
  • , Kun Zhang
  • , Shiping Zhang
  • , Ted Zhang
  • , Yida Zhang
  • , Bingqing Zhao
  • , Wenxin Zhao
  • , Jia Wen Zheng
  • , Sheng Zhong
  • , Bokai Zhu
  • , Chenchen Zhu
  • , Diming Zhu
  • , Quan Zhu
  •  & Ying Zhu

Contributions

S.J., L.P., J.M.S., K.B. and M.P.S. conceived the idea and wrote the first draft of the manuscript and revisions. M.A., J.P.C., N.G., F.G., J.P.G., J.S.H., J.W.H., N.L.K., L.C.L., S.L., Y.L., H.L., A.N., E.S.N., W.-J.Q., A.R., P.R., B.R.S., R.V., I.S.V. and M.Z. contributed to manuscript revision.

Corresponding authors

Correspondence to Sanjay Jain, Liming Pei, Jeffrey M. Spraggins, Katy Börner or Michael P. Snyder.

Ethics declarations

Competing interests

The authors declare the following competing interests. F.G. is an employee of GE Research. B.R.S. is an inventor on patents and patent applications involving small-molecule-drug discovery and the 3F3 anti-Ferroptotic Membrane (3F3-FMA) antibody; co-founded and serves as a consultant to Inzen Therapeutics, Nevrox, Exarta Therapeutics and ProJenX; and serves as a consultant to Weatherwax Biotechnologies and Akin Gump Strauss Hauer and Feld. M.P.S. is a co-founder and an advisory board member of Personalis, Qbio, January AI, Mirvie, Filtricine, Fodsel, Lollo and Protos. I.S.V. consults for Guidepoint Global, Cowen, Mosaic and NextRNA. N.G. is a co-founder and an equity owner of Datavisyn. H.L. is a co-founder and an equity owner of ExoMira Medicine. The remaining authors declare no competing interests.

Peer review

Peer review information

Nature Cell Biology thanks the anonymous reviewers for their contribution to the peer review of this work.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jain, S., Pei, L., Spraggins, J.M. et al. Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP). Nat Cell Biol 25, 1089–1100 (2023). https://doi.org/10.1038/s41556-023-01194-w

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41556-023-01194-w

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing